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entified in this study. © 2020 The Authors. Journal of Clinical Nursing published by John Wiley Sons Ltd.Kisspeptin1 (KISS1) is a tumor metastatic suppressor, and its increased expression is validated in human placenta trophoblast cells. Nonetheless, the actions of KISS1 in hydrogen peroxide (H2 O2 )-impaired human trophoblast HTR8 cells still remain imprecise. This research aims to uncover whether KISS1 can mitigate H2 O2 -triggered cell injury. HTR8 cells were pretreated with 250 μM H2 O2 for 4 hours; the autophagic markers (Bec