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After 18 months of intervention, we observed significant effects for the MetSZ score (p0.001), with significant improvements in the HIT-RT and significant worsening in the CG. In detail, all parameters constituting the MetS contributed to this result, however, only waist-circumference, HDL-cholesterol and mean arterial blood pressure revealed significant effects. No adverse events were reported and high adherence was determined for the HIT-RT-protocol. Continuously supervised HIT-RT is an effective, attractive, feasible and safe meth