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Medication For ADHD - What Are the Side Effects? Many people suffering from ADHD have a decrease in symptoms when they take medication. Every person's reaction to medication is different, and side effects can be a problem. Methylphenidate is a stimulant. It is a stimulant that increases levels of a chemical in the brain that helps regulate behavior and attention. Stimulant medication Stimulant medications enhance attention and concentration in 70 to the 80% of adults and children who take them. They work by altering the activity of neurot