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y relying on RIF susceptibility testing is crucial for improving adherence and outcomes in patients with drug-resistant TB. Copyright © 2020 Zhengwei Liu et al.Caspase recruitment domain family member 8 (CARD8) is an adaptor molecule that negatively regulates nuclear factor-κB (NF-κ activation, interleukin (IL)-1β secretion, and apoptosis. These play important roles in the pathogenesis of psoriasis. Genetic variants of CARD8 have been associated with an increased risk of several inflammatory diseases and psoriasis in Europe. However,