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Furthermore, mTOR inhibition was associated with enhanced PD-L1 expression via TFE3 activation in translocation RCC. These data support the feasibility of combination therapy based on mTOR inhibition and PD-L1 blockade as a novel strategy for the treatment of patients with translocation RCC.Lung adenocarcinoma (LUAD) is a major health problem with minimal prognosis. Heterogeneity is a central determinant of the treatment outcome, requiring the identification of new subclasses of LUAD. Senescence has emerged as a crucial regulator of metas