https://www.selleckchem.com/pr....oducts/epacadostat-i
Botulinum neurotoxin A (BoNT/A) is extremely toxic possessing an estimated intravenous LD of 1-2 ng/kg and as such has been designated a category A bioterrorism agent. BoNT/A also possesses an extremely long half-life and persists within muscle neurons for months to 1 year. Because of BoNT/A longevity, we have utilized covalent inhibition as a means to abrogate BoNT/A's toxicity. To this end, we describe an approach to designing inhibitors that possess both electrophilic warheads and metal-binding groups for the bifun
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