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Taken together, theseresults suggest that the greater clinical effectivenessof the UMP analog sofosbuvir is largely due to itbeing intractable to nucleotide-mediated excisioncompared with similar NAs such as mericitabine.Poly(A)-specific ribonuclease (PARN) is a 3' exoribonuclease that plays an important role in regulating the stability and maturation of RNAs. Recently, PARN has been found to regulate the maturation of the human telomerase RNA component (hTR), a non-coding RNA required for telomere elongation. Specifically, PARN cleave