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tional modeling did not reveal consistent reductions in risky decision-making under tolcapone in gamblers. If anything, tolcapone increased risky choice. Future work should focus on individual genetic, clinical and cognitive factors that might account for heterogeneity in the effects of COMT inhibition. Copyright © 2020 Peters et al.The aging brain is characterized by neural dedifferentiation - an apparent decrease in the functional selectivity of category-selective cortical regions. Age-related reductions in neural differenti