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Ovarian hyperstimulation syndrome is usually an iatrogenic and potentially life-threatening disease. It develops following ovulation induction and use of in vitro fertilization techniques. A 32-year-old primigravida Ethiopian woman presented at 15weeks gestation with a history of progressive bilateral leg swelling and abdominal pain of 2weeks duration. She had triplet pregnancy and conceived through in vitro fertilization. She was managed in intensive care unit. Patients with multiple pregnancy following in vitro fertilization conceptio