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nced centers suggests a need for implementation research in other populations and care settings. Trial Registration ClinicalTrials.gov Identifier NCT02533921.Importance Migraine is one of the most common neurologic disorders in children and adolescents. However, a quantitative comparison of multiple preventive pharmacologic treatments in the pediatric population is lacking. Objective To examine whether prophylactic pharmacologic treatments are more effective than placebo and whether there are differences between drugs regarding efficacy, safety, a