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303). Nausea/vomiting incidence increased with AUC24 (p less then 0.001) and was higher in females. Varenicline PK and ER for tolerability in adolescent smokers were comparable with adults, while ER for efficacy confirmed the negative results reported in the phase 4 study. Blue wavelengths are thought to have an effect on circadian rhythms. Using a smartphone, which emits a 453nm blue light, can worsen the quality of sleep. To study the skin changes caused by poor sleep quality induced by smartphone usage. The participants were 22 Korea