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Additionally, the developed nanocomposite SERS sensors provided the rapid determination of dibenzothiophene and its derivatives in isooctane with the threshold of detection better than 0.1 μM. This approach was successfully applied in the analysis of real fuel samples and the results agreed well with independently measured FTIR and GC-MS data.The stiffness and topography of a cell's extracellular matrix (ECM) are physical cues that play a key role in regulating processes that determine cellular fate and function. While substrate stiffness can dictate cell d