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and context will preserve an original intervention efficacy for autistic children. National Institute for Health Research and Medical Research Council Efficacy and Mechanism Evaluation Award. National Institute for Health Research and Medical Research Council Efficacy and Mechanism Evaluation Award. We aimed to assess the effectiveness of a single dose of the Ad26.COV2.S vaccine (Johnson Johnson) in health-care workers in South Africa during two waves of the South African COVID-19 epidemic. In the single-arm, open-label, phase 3B