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The contribution of geographical distance was similar for both microbial groups. © 2020 The Authors. Environmental Microbiology published by Society for Applied Microbiology and John Wiley Sons Ltd.Atropisomers possessing multiple stereogenic axes are intriguing molecules with huge uncovered potential. As compared with molecules with multiple stereogenic centers for which countless methods exist for their stereocontrolled synthesis, only few approaches have been developed for the enantioselective synthesis of this peculiar class