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To investigate the influence of comprehensive high-quality nursing care on postoperative complications, degree of pain, and nursing satisfaction in gallstone patients during the perioperative period. A total of 77 gallstone patients admitted to our hospital were selected as the study subjects, and divided into a control group (n=38) and an experimental group (n=39) in accordance with the random number table method. During the perioperative period, the control group received conventional nursing, while the experimental group received c