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In the MHCII TME, the immune infiltrate was closer to cancer cells and expressed an activated phenotype. Morphologic image analysis revealed cancer cells in the MHCII TME more frequently interfaced with CD4 and CD8 T cells. Patients with an MHCII TME experienced improved overall survival (p= 0.046). Lung cancer cell-specific expression of MHCII associates with levels of immune cell infiltration, spatial localization, and activation status within the TME. This suggests that cancer cell-specific expression of MHCII may represent a biomar
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