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Aging is generally connected with a cognitive decline and a susceptibility to neuronal damage. It's also the most important risk factor for neurodegenerative conditions, particularly Alzheimer's disease condition (AD). AD is related to an excessive amount of neurotoxic oligomers of amyloid β peptide (Aβo); but, the molecular components are still very controversial. Intracellular Ca2+ homeostasis plays a crucial role into the control over neuronal task, including neurotransmitter release, synaptic