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Failure to make usage of these biomarkers is related to technical and design flaws in the finding and validation phases, but a major hurdle comes from cancer biology itself. Oncogenomics has actually revealed wide hereditary heterogeneity among tumors of the same histology and same tissue (or organ) from various customers, while tumors of various muscle beginnings also share typical hereditary mutations. More over, there was wide intratumor genetic heterogeneity among cells within any single neopla