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Pressure reactivity index (PRx) and brain tissue oxygen (PbtO2) are associated with outcome in TBI. This study explores the relationship between PRx and PbtO2 in adult moderate/severe TBI. Using the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high resolution ICU sub-study cohort, we evaluated those patients with archived high-frequency digital intra-parenchymal ICP and PbtO2 monitoring data of a minimum of 6 hours in duration, and the presence of a 6 month Glasgow Outcome Scale -Extended