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Nevertheless, discover too little experimental and medical data on the use of melatonin on SARS-CoV-2 infection. Accordingly, we created a clinical trial with an injectable formulation of melatonin for intravenous perfusion in ICU clients suffering from COVID-19 that has been only authorized because of the Spanish Agency of Medicines and Medical Devices (AEMPS). The trial will allow by the very first time comprehend the doses and efficacy of melatonin against COVID-19. One of the bigg