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BACKGROUND Hepatic fibrosis is a worldwide incurable disease, due to the complex and unclear mechanism, there lack the effective therapeutic targets. However, the mechanism of miR-23a-5p underling this pathological process is largely not clear. The purpose of this study was to investigate the role of miR-23a-5p in hepatic fibrosis and HSC activation. METHODS The content of miR-23a-5p in hepatic fibrosis induced by N- nitroso two methylamine (NDMA) and HSC activation induced by platelet-derived growth factor (PDGF) was detected by qRT-PC