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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first-choice treatment for ADHD, and for many people, they are effective. Some people have negative side effects or they do not work for everyone. Some doctors prescribe stimulants in addition to non-stimulant ADHD medication. These include medications that treat high blood pressure, for instance Clonidine and Guanfacine hcl (Tenex). They also include others that help to increase awakening. Benefits The first medication doctors pres