https://www.selleckchem.com/pr....oducts/phosphoenolpy
The findings refine our understanding of the molecular basis for KCNQ versus KCNA1 activation and isoform selectivity, and constitute to our knowledge the first reported isoform-selective KCNA1 opener. SIGNIFICANCE STATEMENT Inherited loss-of-function gene sequence variants in KCNA1, which encodes the KCNA1 (Kv1.1) voltage-gated potassium channel, cause Episodic Ataxia Type 1 (EA1) - a movement disorder also linked to epilepsy and developmental delay. We have discovered several isoform-specific KCNA1-a
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