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Fluoride (F-) and nitrate (NO3-) in groundwater have caused serious health problems worldwide. However, in the Chinese Loess Plateau where groundwater is the primary source of drinking water, previous studies have rarely reported the health risks from fluoride and nitrate in groundwater. Therefore, we collected 105 groundwater samples (78 from shallow aquifers and 27 from deep aquifers) from the western district of the Loess Plateau for physicochemical and isotopic analysis to investigate the sources of F- and NO3- in groundwater and a