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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first choice of ADHD drugs, have the most research-based backing behind them, and are quick-acting. But they're not right for everyone. These medications increase the signaling between nerves and areas in the brain, thereby reducing symptoms of ADHD. These medications can also trigger negative side effects, such as a rise in blood pressure or heart rate as well as