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Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1/2) receptors tend to be potential immune checkpoints. In this essay, a quinazolinone derivative (36b) as a NOD1/2 twin antagonist had been identified that significantly sensitizes B16 tumor-bearing mice to paclitaxel treatment by suppressing both atomic aspect κB (NF-κ and mitogen-activated necessary protein kinase inflammatory signaling that mediated by NOD1/2.Curcumin (CCM) is a well-known active element, wh