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Therefore, the antimicrobial diarrhea function of DESP may be related to the regulation of intestinal microbiota.The purpose of this study was to evaluate the impact of the BRAINballs program on second graders' gross motor skills in a primary school in Vietnam. A total of 55 students (23 boys and 32 girls) aged seven years participated in the study. The research used the method of a pedagogical experiment and parallel group technique (experimental and control group) with pre- and post-testing. The study was conducted in the school year 2