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Since the 2000s, creation of pitahaya (Hylocereus spp.) has increased substantially in Southern Florida. But, not a lot of info is offered from the primary diseases affecting this crop, particularly in respect to disease epidemiology and economic affect the product. In this study, we surveyed five neighborhood pitahaya orchards and documented more common conditions and their causal representatives. Three genera of fungal pathogens (Neoscytalidium, Alternaria,