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A significant correlation was demonstrated between Xe VDP and He VDP for both GRE and TrueFISP sequences (ρ = 0.78, p0.0004). The correlation between the GRE and TrueFISP VDP for He was ρ = 0.98 and was ρ = 0.91 for Xe. Overall, Xe (27.2±9.4) VDP was higher than He (24.3±6.9) VDP on average on cystic fibrosis patients. In patients with cystic fibrosis, the selection of hyperpolarized Xe or He gas is most likely inconsequential when it comes to measure the overall lung function by VDP although Xe may be more sensitive to starker lun