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However, upon carcinogenesis, TNTs proliferate and provide an alternative route of communication to enable the transfer of several signaling molecules and organelles to spread disease and toxicity. We propose that TNTs and their cargo are an attractive therapeutic target to reduce or prevent cancer development. All these unique aspects of cell-to-cell diffusion and organelle sharing will be discussed in this special issue.This study aimed to evaluate the influence of dietary supplementation with curcumin in a native (CUR) or solid nanopa