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Challenging emergency caring situations can contribute to compassion fatigue and burnout among emergency nurses. These variables have been widely researched, although not among Chinese nurses. Pertinent findings will extend the international literature in this domain. This study aimed to develop and test a model that delineates the predictive relationship that empathy, self-compassion, job satisfaction, individual and work-related factors share with compassion fatigue, burnout, and compassion satisfaction. A cross-sectional survey