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7 (22.4-26.5)L. The mean mTNS (SE) worsened by 1.7 (0.4)/28 and 1.2 (0.4)/28 in the hemodiafiltration and hemodialysis groups respectively, with a mean difference of 0.5 (95% confidence interval -0.7 to 1.7, p=0.37). There was no difference in survival (HR 1.24 (0.61 to 2.51), log rank p=0.55) or any of the pre-specified adverse events. There was no difference between groups in the number of participants who suffered an adverse event adjusted by follow-up time (Relative risk 1.05 (0.83-1.32) p=0.68). Neuropathy is still a common complicat