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Adult ADHD and Comorbid Disorders Many adults suffering from ADHD also have comorbid disorders like major depression (Kessler and colleagues 2006). Many patients are not responsive to depression medications and may benefit from psychotherapy. Neurotransmitters are brain chemicals that regulate and increase levels of certain brain chemicals. The most commonly prescribed stimulants are amphetamine, methylphenidate, and similar drugs. Medicines Adults can take a variety of medications t