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95, 3.97, 2.08 IU/L respectively) compared to untreated group before a significant increase was observed for day 60 and 90. Progesterone increased dose-dependently in the treated groups throughout the 90-day treatment duration. This may be Indicating cumulative effect on the hormone. No deleterious or toxicity effect was noticed. The extract of Persea americana seed affects female hormone activity. This may find application in various hormonal management procedures, maternal and reproductive health and fertility control/help health fac