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Environmental exposures have profound effects on health and disease. While public repositories exist for a variety of exposures data, these are generally difficult to access, navigate, and interpret. We describe the research, development, and application of three open application programming interfaces (APIs) that support access to usable, nationwide, exposures data from three public repositories airborne pollutant estimates from the US Environmental Protection Agency; roadway data from the US Department of Transportation; and socio-envi