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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If someone has ADHD and anxiety or depression treating one of the conditions often improves the other. Mental health professionals usually prescribe antidepressants or a stimulant for depression in addition to an ADHD medication. Wellbutrin (bupropion) and Effexor, (venlafaxine), are the two most common antidepressants that are prescribed for ADHD "off-label". These medications boost the levels of neurotransmitters dopa