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CNN testing was performed on data from crystals not included in CNN training. An average DOI resolution of 1.84mm full width at half maximum (FWHM) across all crystals was achieved when using all readout signals per event with the CNN compared to 3.04mm FWHM DOI resolution using classical estimation. When using only the 4 highest signals per event, an average DOI resolution of 1.92mm FWHM was achieved, representing only a 4% dropoff in CNN performance compared to using all non-zero pixels per event. Our CNN-based DOI es