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05). Multivariable logistic regression revealed that high ferritin (1922.58 ng/mL), low platelets (101 × 10 /L) and high triglycerides (2.28 mmol/L) were independent risk factors for suspected sHLH in COVID-19 patients. Importantly, COVID-19 patients that were suspected sHLH positive had significantly more multi-organ failure. Additionally, a high HScore (98) was an independent predictor for mortality in COVID-19. HScore should be measured as a prognostic biomarker in COVID-19 patients. In particular, it is important th