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9 ± 10.6, vs. after 49.2 ± 9.. A similar decrease (P 0.001) was observed in the DSO group (before 64.1 ± 11.3, vs. after 41.3 ± 8.. The decrease of the WOMAC score in the third and sixteenth weeks after providing the intervention was significant in the DSO group compared to the DS group (P 0.005). For patients with knee OA, prolotherapy with ozone plus hypertonic dextrose and somatropin was more effective in sedating the pain and improving the stiffness and function of the knee than dextrose and somatropin alone. For pati