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Hemoglobin A (HbA ) and glycated albumin (GA) are glycemic control status indicators in patients with diabetes mellitus. Hemoglobin H (HbH) disease is a moderately severe form of α-thalassemia. Here we examine the usefulness of HbA and GA in monitoring glycemic control in patients with HbH disease. HbA , GA, and an oral glucose tolerance test were performed in 85 patients with HbH disease and 130 healthy adults. HbA was measured using five methods, including two systems based on cation-exchange high-performance liquid chromatography (V