https://www.selleckchem.com/pr....oducts/tiragolumab-a
BACKGROUND Human endothelin-1 (ET-1) gene polymorphism is closely associated with coronary artery disease (CAD). This study aimed to investigate the association of 2 single-nucleotide polymorphisms (SNPs), +138 I/D and Lys198Asn) of the ET-1 gene,with early onset of CAD in Han Chinese patients. We investigated the effects of Lys198Asn polymorphism on ET-1 protein expression upon stimulation with pro-inflammatory factors. MATERIAL AND METHODS Genotyping of the 2 SNPs +138 I/D and Lys198Asn was performed in 88 early-onset C