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Moreover, the follow-up analysis results showed that, as the treatment progressed, the differences in the 3 serum ceramide species were statistically significant. There was a stage-specific association between serum ceramides and PSD, and the potential pathophysiological mechanism has to be investigated in future research. There was a stage-specific association between serum ceramides and PSD, and the potential pathophysiological mechanism has to be investigated in future research.Gitelman syndrome (GS) is an autosomal recessive disorder