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Background Proper education can improve the quality of life. Multimedia as an interactive educational method and booklet as a traditional one have their own unique effects. This study aimed at compare the interactive multimedia and booklet methods at the time of discharge on the quality of life of kidney transplant patients. Methods In this single-blind interventional study, 80 patients from Bouali Hospital, Shiraz, from September 2017 until June 2018 were selected by convenience sampling, and then divided into two groups (booklet and