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Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Objective In this work ZnO-nanorod (ZnO-NR) as reusable catalyst promoted Strecker-type reaction of 2,4-dihydroxyacetophenone, isopropenylacetylene, trimethylsilyl cyanide (TMSCN), primary amines and isocyanides carried out at ambient temperature under solvent-free conditions and produced α-amino nitriles benzofuran derivatives in high yields. These synthesized compounds maybe have antioxidant ability. MATERIALS AND METHODS ZnO-NRs in these reactions w