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STATEMENT OF SIGNIFICANCE We identify a structure-function relationship in tooth enamels from different species crystal misorientation correlates with hardness, contributing to the remarkable mechanical properties of enamel in diverse animals.Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro