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In this issue of Neuron, Park et al. (202 show that the brain forms unified cognitive maps of relational knowledge. The hippocampal-entorhinal region and medial prefrontal cortices spontaneously combine multiple, distinct rank orders to two-dimensional cognitive maps enabling flexible inference.In this issue, Laukoter et al., 2020 report that parent-of-origin-dependent expression is homogeneous across distinct cortical cell types and within individual populations. Conversely, they observe preferential sensitivity of astrocytes to altered doses of imprinte