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Early-onset colorectal cancer (EO-CRC) is a public health concern. Starting screening at 45years has been considered, but there is discrepancy in the recommendations. Racial disparities in EO-CRC incidence and survival are reported; however, racial/ethnic differences in EO-CRC features that could inform a racial/ethnic-tailored CRC screening strategy have not been reported. We compared features and survival among Non-Hispanic White (NHW), Non-Hispanic Black (NH, and Hispanics with EO-CRC. CRC patients from SEER 1973-2010 database wer