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The QIAstat-Dx® Respiratory Panel V2 (RP) is a novel molecular-based syndromic test for the simultaneous and rapid (∼70 minutes) detection of 18 viral and three bacterial pathogens causing respiratory infections. This study describes the first multicenter retrospective comparison of the performance of the QIAstat-Dx® RP assay to the established ePlex® Respiratory Pathogen Panel (RPP) assay, for which we used 287 respiratory samples from patients suspected with respiratory infections. The QIAstat-Dx® RP assay detected 312 of the 338 respi