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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If someone has ADHD and depression or anxiety, treating one condition often improves the other. Mental health professionals prescribe antidepressants, stimulants for depression, or antidepressants, along with ADHD medication. Wellbutrin (bupropion), and Effexor, (venlafaxine), are two of the most popular antidepressants prescribed to treat ADHD "off-label". These drugs increase the levels of neurotransmitters dopamine as well as norepinephrine. They also improve concen