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Our study identified a novel inducer, acetate, which can promote SNAI1 expression by ACSS2-mediated histone acetylation in partly. This finding has important implication in treatment of metastatic cancers.Basimglurant (RG709, a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes (FAH) in a long-term rodent-toxicity study. Additional evidence pointed towards the activation of the constitutive androstane receptor (CAR), an established promoter of non-genotoxic and rodent-speci